8PDI

The phosphatase and C2 domains of SHIP1 with covalent Z1763271112

8PDI の概要

• エントリーDOI: 10.2210/pdb8pdi/pdb
• 分子名称: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, (5-phenyl-1,3,4-thiadiazol-2-yl)methanimine, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: ligand, phoshphatase, c2, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53301.21

構造登録者

Bradshaw, W.J.,Moreira, T.,Pascoa, T.C.,Bountra, C.,Chalk, R.,von Delft, F.,Brennan, P.E.,Gileadi, O. (登録日: 2023-06-12, 公開日: 2023-07-26, 最終更新日: 2024-04-17)

• 主引用文献: Bradshaw, W.J.,Kennedy, E.C.,Moreira, T.,Smith, L.A.,Chalk, R.,Katis, V.L.,Benesch, J.L.P.,Brennan, P.E.,Murphy, E.J.,Gileadi, O.; Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.; Structure, 32:453-, 2024; PubMed: 38309262; DOI: 10.1016/j.str.2024.01.005

実験手法

X-RAY DIFFRACTION (1.3 Å)