8PC7

STRUCTURE OF ESTER-HYDROLASE EH3 FROM THE METAGENOME OF MARINE SEDIMENTS AT MILAZZO HARBOR (SICILY, ITALY) COMPLEXED WITH A DERIVATIVE OF BIPYRIDINE PHOSPHONATE

8PC7 の概要

• エントリーDOI: 10.2210/pdb8pc7/pdb
• 関連するPDBエントリー: 6SXP 6SXY 6SYA 6SYL
• 分子名称: Esterase, DI(HYDROXYETHYL)ETHER, hexyl-[2-(3-oxidanylpyridin-2-yl)pyridin-3-yl]oxy-phosphinic acid, ... (5 entities in total)
• 機能のキーワード: ester hydrolase, complex, hydrolase
• 由来する生物種: metagenome
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 162810.07

構造登録者

Cea-Rama, I.,Sanz-Aparicio, J. (登録日: 2023-06-09, 公開日: 2023-07-19, 最終更新日: 2024-11-06)

主引用文献

Fernandez-Lopez, L.,Cea-Rama, I.,Alvarez-Malmagro, J.,Ressmann, A.K.,Gonzalez-Alfonso, J.L.,Coscolin, C.,Shahgaldian, P.,Plou, F.J.,Modregger, J.,Pita, M.,Sanz-Aparicio, J.,Ferrer, M.
Transforming an esterase into an enantioselective catecholase through bioconjugation of a versatile metal-chelating inhibitor.
Chem.Commun.(Camb.), 59:9469-9472, 2023

PubMed Abstract: Metal complexes introduced into protein scaffolds can generate versatile biomimetic catalysts endowed with a variety of catalytic properties. Here, we synthesized and covalently bound a bipyridinyl derivative to the active centre of an esterase to generate a biomimetic catalyst that shows catecholase activity and enantioselective catalytic oxidation of (+)-catechin.

PubMed: 37376994
DOI: 10.1039/d3cc01946b

実験手法

X-RAY DIFFRACTION (2.4 Å)