8PBK

Mutant R1722W of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoorotate

Summary for 8PBK

Entry DOI	10.2210/pdb8pbk/pdb
Related	8PBE 8PBG 8PBH 8PBI 8PBJ
Descriptor	CAD protein, 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, GLYCEROL, ... (6 entities in total)
Functional Keywords	nucleotide metabolism, de novo pyrimidine synthesis, cad disease, multienzymatic protein, zinc, carboxylated lysine, biosynthetic protein, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	40258.52
Authors	del Cano-Ochoa, F.,Ramon-Maiques, S. (deposition date: 2023-06-09, release date: 2023-11-01, Last modification date: 2023-11-22)
Primary citation	Del Cano-Ochoa, F.,Ng, B.G.,Rubio-Del-Campo, A.,Mahajan, S.,Wilson, M.P.,Vilar, M.,Rymen, D.,Sanchez-Pintos, P.,Kenny, J.,Ley Martos, M.,Campos, T.,Wortmann, S.B.,Freeze, H.H.,Ramon-Maiques, S. Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46:1170-1185, 2023 Cited by PubMed: 37540500 DOI: 10.1002/jimd.12667 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation