8PAV

Crystal structure of MST1 with a MAP4K1 SMOL inhibitor

Summary for 8PAV

• Entry DOI: 10.2210/pdb8pav/pdb
• Descriptor: Serine/threonine-protein kinase 4 37kDa subunit, 1-[3,5-bis(fluoranyl)-4-[[3-(1,3-thiazol-5-yl)-1~{H}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-3-(2-methoxyethyl)urea, GLYCEROL, ... (5 entities in total)
• Functional Keywords: kinase, inhibitor, drug discovery, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 72487.81

Authors

Friberg, A. (deposition date: 2023-06-08, release date: 2024-06-26)

• Primary citation: Friberg, A.,Mowat, J.,Offringa, R.; Identification and optimization of Azaindole based MAP4K1 Inhibitors and the discovery of BAY-405; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)