8P9W

vitamin D receptor complex with Xe4MeCF3 analog

8P9W の概要

• エントリーDOI: 10.2210/pdb8p9w/pdb
• 分子名称: Vitamin D3 receptor A, Nuclear receptor coactivator 1, (1~{R},3~{S},5~{Z})-5-[(2~{E})-2-[(1~{S},3~{a}~{S},7~{a}~{S})-1,7~{a}-dimethyl-1-[6,6,6-tris(fluoranyl)-5-oxidanyl-5-(trifluoromethyl)hexa-1,3-diynyl]-2,3,3~{a},5,6,7-hexahydroinden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, agonist, ligand binding domain, transcription
• 由来する生物種: Danio rerio (zebrafish); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36353.26

構造登録者

Belorusova, A.Y.,Rochel, N. (登録日: 2023-06-06, 公開日: 2024-06-26, 最終更新日: 2024-10-16)

主引用文献

Len-Tayon, K.,Beraud, C.,Fauveau, C.,Belorusova, A.Y.,Chebaro, Y.,Mourino, A.,Massfelder, T.,Chauchereau, A.,Metzger, D.,Rochel, N.,Laverny, G.
A vitamin D-based strategy overcomes chemoresistance in prostate cancer.
Br.J.Pharmacol., 181:4279-4293, 2024

PubMed Abstract: Castration-resistant prostate cancer (CRPC) is a common male malignancy that requires new therapeutic strategies due to acquired resistance to its first-line treatment, docetaxel. The benefits of vitamin D on prostate cancer (PCa) progression have been previously reported. This study aimed to investigate the effects of vitamin D on chemoresistance in CRPC.

PubMed: 38982588
DOI: 10.1111/bph.16492

実験手法

X-RAY DIFFRACTION (2.9 Å)