8P9J

Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB500

Summary for 8P9J

• Entry DOI: 10.2210/pdb8p9j/pdb
• Descriptor: Bromodomain-containing protein 4, ~{N}-(2-aminophenyl)-5-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)pyridine-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bromodomain, epigenetic drugs, inhibitor, cancer therapy, gene regulation
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15893.24

Authors

Balourdas, D.I.,Bauer, N.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2023-06-06, release date: 2023-07-05)

• Primary citation: Balourdas, D.I.,Bauer, N.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC); Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB500; to be published,

Experimental method

X-RAY DIFFRACTION (1.42 Å)