8P9J

Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB500

8P9J の概要

• エントリーDOI: 10.2210/pdb8p9j/pdb
• 分子名称: Bromodomain-containing protein 4, ~{N}-(2-aminophenyl)-5-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)pyridine-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: bromodomain, epigenetic drugs, inhibitor, cancer therapy, gene regulation
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15893.24

構造登録者

Balourdas, D.I.,Bauer, N.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (登録日: 2023-06-06, 公開日: 2023-07-05)

• 主引用文献: Balourdas, D.I.,Bauer, N.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC); Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB500; to be published,

実験手法

X-RAY DIFFRACTION (1.42 Å)