8P9H
Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB437
Summary for 8P9H
Entry DOI | 10.2210/pdb8p9h/pdb |
Descriptor | Bromodomain-containing protein 4, ~{N}-(2-aminophenyl)-2-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)quinoline-6-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain, epigenetic drugs, inhibitor, cancer therapy, gene regulation |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 15819.16 |
Authors | Balourdas, D.I.,Bauer, N.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2023-06-06, release date: 2023-07-05) |
Primary citation | Balourdas, D.I.,Bauer, N.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB437 to be published, |
Experimental method | X-RAY DIFFRACTION (1.19 Å) |
Structure validation
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