8P6Y
Cryo-EM structure of CAK in complex with nucleotide analogue ATPgS
Summary for 8P6Y
Entry DOI | 10.2210/pdb8p6y/pdb |
Related | 8ORM |
EMDB information | 17129 17511 |
Descriptor | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... (6 entities in total) |
Functional Keywords | kinase, inhibitor, transcription, cell cycle, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 87866.19 |
Authors | Cushing, V.I.,Koh, A.F.,Feng, J.,Jurgaityte, K.,Bahl, A.K.,Ali, S.,Kotecha, A.,Greber, B.J. (deposition date: 2023-05-30, release date: 2023-08-30, Last modification date: 2024-03-27) |
Primary citation | Cushing, V.I.,Koh, A.F.,Feng, J.,Jurgaityte, K.,Bondke, A.,Kroll, S.H.B.,Barbazanges, M.,Scheiper, B.,Bahl, A.K.,Barrett, A.G.M.,Ali, S.,Kotecha, A.,Greber, B.J. High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15:2265-2265, 2024 Cited by PubMed: 38480681DOI: 10.1038/s41467-024-46375-9 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (1.9 Å) |
Structure validation
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