8P64

Co-crystal structure of PD-L1 with low molecular weight inhibitor

Summary for 8P64

Entry DOI	10.2210/pdb8p64/pdb
Descriptor	Programmed cell death 1 ligand 1, ~{N}-[[1-[(~{E})-2-(2-methyl-3-phenyl-phenyl)ethenyl]-1,2,3,4-tetrazol-5-yl]methyl]ethanamine (3 entities in total)
Functional Keywords	pd-l1, inhibitor complex, antitumor protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	30227.57
Authors	Plewka, J.,Magiera-Mularz, K.,van der Straat, R.,Draijer, R.,Surmiak, E.,Butera, R.,Land, L.,Musielak, B.,Domling, A. (deposition date: 2023-05-25, release date: 2024-03-06, Last modification date: 2024-05-15)
Primary citation	van der Straat, R.,Draijer, R.,Surmiak, E.,Butera, R.,Land, L.,Magiera-Mularz, K.,Musielak, B.,Plewka, J.,Holak, T.A.,Domling, A. 1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists. Rsc Med Chem, 15:1210-1215, 2024 Cited by PubMed: 38665826 DOI: 10.1039/d3md00746d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.312 Å)

Structure validation