8P4J

Alpha-1-antitrypsin - Sydney variant (G192C)

Summary for 8P4J

Entry DOI	10.2210/pdb8p4j/pdb
Descriptor	Alpha-1-antitrypsin (2 entities in total)
Functional Keywords	alpha-1-antitrypsin, serine protease inhibitor, alpha-1-antitrypsin deficiency, conformational disease, rare variant, serpin, protein binding
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	45225.32
Authors	Kamuda, K.,Lomas, D.A.,Irving, J.A. (deposition date: 2023-05-22, release date: 2024-04-03)
Primary citation	Kamuda, K.,Ronzoni, R.,Majumdar, A.,Guan, F.H.X.,Irving, J.A.,Lomas, D.A. A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate. Febs J., 2024 Cited by PubMed: 38523412 DOI: 10.1111/febs.17121 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation