8P44
Crystal structure of monkeypox virus poxin in complex with the STING agonist MD1202D
Summary for 8P44
Entry DOI | 10.2210/pdb8p44/pdb |
Descriptor | MPXVgp165, 9-[(1~{S},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one (3 entities in total) |
Functional Keywords | mpox, monkeypox, virus, poxin, viral protein |
Biological source | Monkeypox virus |
Total number of polymer chains | 4 |
Total formula weight | 92813.72 |
Authors | Duchoslav, V.,Klima, M.,Boura, E. (deposition date: 2023-05-19, release date: 2023-12-20, Last modification date: 2024-04-17) |
Primary citation | Klima, M.,Dejmek, M.,Duchoslav, V.,Eisenreichova, A.,Sala, M.,Chalupsky, K.,Chalupska, D.,Novotna, B.,Birkus, G.,Nencka, R.,Boura, E. Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function. Structure, 32:433-, 2024 Cited by PubMed: 38325369DOI: 10.1016/j.str.2024.01.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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