8P33

BB0238 from Borrelia burgdorferi

Summary for 8P33

• Entry DOI: 10.2210/pdb8p33/pdb
• Descriptor: BB0238 (2 entities in total)
• Functional Keywords: lyme disease, borreliosis, outer surface protein, immune evasion, membrane protein
• Biological source: Borreliella burgdorferi B31
• Total number of polymer chains: 1
• Total formula weight: 16368.25

Authors

Brangulis, K.,Foor, S.D.,Shakya, A.K.,Rana, V.S.,Bista, S.,Kitsou, C.,Ronzetti, M.,Linden, S.B.,Altieri, A.S.,Akopjana, I.,Baljinnyam, B.,Nelson, D.C.,Simeonov, A.,Herzberg, O.,Caimano, M.J.,Pal, U. (deposition date: 2023-05-16, release date: 2023-10-11, Last modification date: 2023-11-29)

Primary citation

Foor, S.D.,Brangulis, K.,Shakya, A.K.,Rana, V.S.,Bista, S.,Kitsou, C.,Ronzetti, M.,Alreja, A.B.,Linden, S.B.,Altieri, A.S.,Baljinnyam, B.,Akopjana, I.,Nelson, D.C.,Simeonov, A.,Herzberg, O.,Caimano, M.J.,Pal, U.
A unique borrelial protein facilitates microbial immune evasion.
Mbio, 14:e0213523-e0213523, 2023

PubMed Abstract: Lyme disease is a major tick-borne infection caused by a bacterial pathogen called , which is transmitted by ticks and affects hundreds of thousands of people every year. These bacterial pathogens are distinct from other genera of microbes because of their distinct features and ability to transmit a multi-system infection to a range of vertebrates, including humans. Progress in understanding the infection biology of Lyme disease, and thus advancements towards its prevention, are hindered by an incomplete understanding of the microbiology of , partly due to the occurrence of many unique borrelial proteins that are structurally unrelated to proteins of known functions yet are indispensable for pathogen survival. We herein report the use of diverse technologies to examine the structure and function of a unique protein, annotated as BB0238-an essential virulence determinant. We show that the protein is structurally organized into two distinct domains, is involved in multiplex protein-protein interactions, and facilitates tick-to-mouse pathogen transmission by aiding microbial evasion of early host cellular immunity. We believe that our findings will further enrich our understanding of the microbiology of potentially impacting the future development of novel prevention strategies against a widespread tick-transmitted infection.

PubMed: 37830812
DOI: 10.1128/mbio.02135-23

Experimental method

X-RAY DIFFRACTION (2.1 Å)