8P22

X-ray structure of acetylcholine-binding protein (AChBP) in complex with IOTA376.

Summary for 8P22

• Entry DOI: 10.2210/pdb8p22/pdb
• Descriptor: Acetylcholine-binding protein, 2-[(2~{R})-1-ethylimidazolidin-2-yl]-6-pyridin-2-yl-pyridine, SULFATE ION, ... (5 entities in total)
• Functional Keywords: fragment based drug design, acetylcholine-binding protein, choline-binding proteins, choline-binding protein
• Biological source: Lymnaea stagnalis (great pond snail)
• Total number of polymer chains: 10
• Total formula weight: 237209.54

Authors

Cederfelt, D.,Boronat, P.,Dobritzsch, D.,Hennig, S.,Fitzgerald, E.A.,de Esch, I.J.P.,Danielson, U.H. (deposition date: 2023-05-14, release date: 2024-05-08)

• Primary citation: Fitzgerald, E.A.,Cederfelt, D.,Boronat, P.,Aarmo Lund, B.,Dobritzsch, D.,de Esch, I.J.P.,Danielson, U.H.; Elucidating the regulation of ligand gated ion channels via biophysical studies of ligand-induced conformational dynamics of acetylcholine binding proteins; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)