8P1T

Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor Z237451470

これはPDB形式変換不可エントリーです。

8P1T の概要

• エントリーDOI: 10.2210/pdb8p1t/pdb
• 分子名称: S-adenosylmethionine synthase isoform type-2, S-ADENOSYLMETHIONINE, 6-cyclopropyl-~{N}-(1~{H}-indazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-b]pyridine-4-carboxamide, ... (7 entities in total)
• 機能のキーワード: methionine adenosyltransferase, s-adenosylmethionine synthase isoform 2 type-2, sam, allosteric inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46893.38

構造登録者

Thomsen, M.,Thieulin-Pardo, G.,Neumann, L. (登録日: 2023-05-12, 公開日: 2023-08-30)

• 主引用文献: Kalliokoski, T.,Kettunen, H.,Kumpulainen, E.,Kettunen, E.,Thieulin-Pardo, G.,Neumann, L.,Thomsen, M.,Paul, R.,Malyutina, A.,Georgiadou, M.; Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening.; Bioorg.Med.Chem.Lett., 94:129450-129450, 2023; PubMed: 37591318; DOI: 10.1016/j.bmcl.2023.129450

実験手法

X-RAY DIFFRACTION (1.442 Å)