8P0Y

The crystal structure of the C-terminal domain of Mengla nucleoprotein

8P0Y の概要

• エントリーDOI: 10.2210/pdb8p0y/pdb
• 分子名称: Nucleoprotein, C-terminal domain of Mengla nucleoprotein, ... (4 entities in total)
• 機能のキーワード: nucleoprotein, viral protein, filovirus, mengla
• 由来する生物種: Mengla dianlovirus; 詳細
• タンパク質・核酸の鎖数: 17
• 化学式量合計: 206067.17

構造登録者

Ferrero, D.S.,Tomas Gilabert, O.,Verdaguer, N. (登録日: 2023-05-11, 公開日: 2023-10-25, 最終更新日: 2023-12-27)

主引用文献

Ferrero, D.S.,Tomas Gilabert, O.,Verdaguer, N.
Structural insights on the nucleoprotein C-terminal domain of Mengla virus.
Microbiol Spectr, 11:e0237323-e0237323, 2023

PubMed Abstract: Filoviruses are the causative agents of severe and often fatal hemorrhagic disease in humans. Měnglà virus (MLAV) is a recently reported filovirus, isolated from fruit bats that is capable to replicate in human cells, representing a potential risk for human health. An in-depth structural and functional knowledge of MLAV proteins is an essential step for antiviral research on this virus that can also be extended to other emerging filoviruses. In this study, we determined the first crystal structures of the C-terminal domain (CTD) of the MLAV nucleoprotein (NP), showing important similarities to the equivalent domain in MARV. The structural data also show that the NP CTD has the ability to form large helical oligomers that may participate in the control of cytoplasmic inclusion body formation during viral replication.

PubMed: 37888996
DOI: 10.1128/spectrum.02373-23

実験手法

X-RAY DIFFRACTION (4.12 Å)