8P05

Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with Leucettinib-92

8P05 の概要

• エントリーDOI: 10.2210/pdb8p05/pdb
• 分子名称: Casein kinase II subunit alpha, SULFATE ION, (4~{Z})-2-(1-adamantylamino)-4-(1,3-benzothiazol-6-ylmethylidene)-1~{H}-imidazol-5-one, ... (4 entities in total)
• 機能のキーワード: kinase, ck2a, csnk2a1, inhibitor, leucettinib, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82565.69

構造登録者

Kraemer, A.,Meijer, L.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2023-05-09, 公開日: 2023-05-17, 最終更新日: 2023-11-22)

• 主引用文献: Deau, E.,Lindberg, M.F.,Miege, F.,Roche, D.,George, N.,George, P.,Kramer, A.,Knapp, S.,Meijer, L.; Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B.; J.Med.Chem., 66:10694-10714, 2023; PubMed: 37487467; DOI: 10.1021/acs.jmedchem.3c00884

実験手法

X-RAY DIFFRACTION (2.45 Å)