8OZ3

Crystal structure of scFv ATOR 1017 bound to human 4-1BB

8OZ3 の概要

• エントリーDOI: 10.2210/pdb8oz3/pdb
• 分子名称: Single chain Fv, Tumor necrosis factor receptor superfamily member 9, ... (4 entities in total)
• 機能のキーワード: complex, single chain fv, tumor necrosis factor, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 126341.00

構造登録者

Hakansson, M.,Von Schantz, L.,Rose, N. (登録日: 2023-05-08, 公開日: 2024-03-13, 最終更新日: 2024-11-06)

主引用文献

Enell Smith, K.,Fritzell, S.,Nilsson, A.,Barchan, K.,Rosen, A.,Schultz, L.,Varas, L.,Sall, A.,Rose, N.,Hakansson, M.,von Schantz, L.,Ellmark, P.
ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1.
Cancer Immunol.Immunother., 72:4145-4159, 2023

PubMed Abstract: 4-1BB (CD137) is a co-stimulatory receptor highly expressed on tumor reactive effector T cells and NK cells, which upon stimulation prolongs persistence of tumor reactive effector T and NK cells within the tumor and induces long-lived memory T cells. 4-1BB agonistic antibodies have been shown to induce strong anti-tumor effects that synergize with immune checkpoint inhibitors. The first generation of 4-1BB agonists was, however, hampered by dose-limiting toxicities resulting in suboptimal dose levels or poor agonistic activity.

PubMed: 37796298
DOI: 10.1007/s00262-023-03548-7

実験手法

X-RAY DIFFRACTION (3.1 Å)