8OX8

Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited "open" conformation

Summary for 8OX8

Entry DOI	10.2210/pdb8ox8/pdb
EMDB information	17260
Descriptor	Phospholipid-transporting ATPase IC, Cell cycle control protein 50A, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	lipid transporter autoinhibition p-type atpase p4-atpase cdc50a, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	186942.57
Authors	Dieudonne, T.,Kummerer, F.,Juknaviciute Laursen, M.,Stock, C.,Kock Flygaard, R.,Khalid, S.,Lenoir, G.,Lyons, J.A.,Lindorff-Larsen, K.,Nissen, P. (deposition date: 2023-05-01, release date: 2023-11-29)
Primary citation	Dieudonne, T.,Kummerer, F.,Laursen, M.J.,Stock, C.,Flygaard, R.K.,Khalid, S.,Lenoir, G.,Lyons, J.A.,Lindorff-Larsen, K.,Nissen, P. Activation and substrate specificity of the human P4-ATPase ATP8B1. Nat Commun, 14:7492-7492, 2023 Cited by PubMed: 37980352 DOI: 10.1038/s41467-023-42828-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.98 Å)

Structure validation