8OWL

SR Ca(2+)-ATPase in the E2 state complexed with the photoswitch-thapsigargin derivative AzTG-6

Summary for 8OWL

• Entry DOI: 10.2210/pdb8owl/pdb
• Related: 8OWA
• Descriptor: Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, ACETYL GROUP, [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-3,3a-bis(oxidanyl)-2-oxidanylidene-4-[6-[4-[(E)-phenyldiazenyl]phenyl]hexanoyloxy]-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate, ... (4 entities in total)
• Functional Keywords: serca inhibitors, photoswitch, azobenzene, thapsigargin, hydrolase
• Biological source: Oryctolagus cuniculus (rabbit)
• Total number of polymer chains: 1
• Total formula weight: 110229.31

Authors

Hjorth-Jensen, S.J.,Konrad, D.B.,Quistgaard, E.M.H.,Hansen, L.C.,Novak, A.,Chu, H.,Jurasek, M.,Zimmermann, T.,Andersen, J.L.,Baran, P.S.,Nissen, P.,Trauner, D. (deposition date: 2023-04-28, release date: 2023-06-21)

• Primary citation: Hjorth-Jensen, S.J.,Konrad, D.B.,Quistgaard, E.M.H.,Hansen, L.C.,Novak, A.,Chu, H.,Jurasek, M.,Zimmermann, T.,Andersen, J.L.,Baran, P.S.,Nissen, P.,Trauner, D.; Photoswitchable inhibitors of the sarco(endo)plasmic calcium pump; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.02 Å)