8OWL

SR Ca(2+)-ATPase in the E2 state complexed with the photoswitch-thapsigargin derivative AzTG-6

8OWL の概要

• エントリーDOI: 10.2210/pdb8owl/pdb
• 関連するPDBエントリー: 8OWA
• 分子名称: Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, ACETYL GROUP, [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-3,3a-bis(oxidanyl)-2-oxidanylidene-4-[6-[4-[(E)-phenyldiazenyl]phenyl]hexanoyloxy]-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate, ... (4 entities in total)
• 機能のキーワード: serca inhibitors, photoswitch, azobenzene, thapsigargin, hydrolase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 110229.31

構造登録者

Hjorth-Jensen, S.J.,Konrad, D.B.,Quistgaard, E.M.H.,Hansen, L.C.,Novak, A.,Chu, H.,Jurasek, M.,Zimmermann, T.,Andersen, J.L.,Baran, P.S.,Nissen, P.,Trauner, D. (登録日: 2023-04-28, 公開日: 2023-06-21)

• 主引用文献: Hjorth-Jensen, S.J.,Konrad, D.B.,Quistgaard, E.M.H.,Hansen, L.C.,Novak, A.,Chu, H.,Jurasek, M.,Zimmermann, T.,Andersen, J.L.,Baran, P.S.,Nissen, P.,Trauner, D.; Photoswitchable inhibitors of the sarco(endo)plasmic calcium pump; To Be Published,

実験手法

X-RAY DIFFRACTION (3.02 Å)