8OU8

Crystal structure of E. coli threonyl tRNA synthetase in complex with a TM84 analogue

Summary for 8OU8

Entry DOI	10.2210/pdb8ou8/pdb
Descriptor	Threonine--tRNA ligase, [(2~{S},4~{S},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-oxolan-2-yl]methoxy-~{N}-[(2~{S},3~{S})-2-azanyl-3-oxidanyl-butanoyl]phosphonamidic acid, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywords	threonyl trna synthetase, e. coli, inhibitor, complex, rna binding protein
Biological source	Escherichia coli IAI1
Total number of polymer chains	2
Total formula weight	97271.09
Authors	Rodriguez Buitrago, J.A.,Parisini, E.,Aigars, J. (deposition date: 2023-04-22, release date: 2023-07-12, Last modification date: 2023-09-06)
Primary citation	Buitrago, J.A.R.,Leitis, G.,Kanepe-Lapsa, I.,Rudnickiha, A.,Parisini, E.,Jirgensons, A. Synthesis and evaluation of an agrocin 84 toxic moiety (TM84) analogue as a malarial threonyl tRNA synthetase inhibitor. Org.Biomol.Chem., 21:5433-5439, 2023 Cited by PubMed: 37335076 DOI: 10.1039/d3ob00670k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation