8OU8

Crystal structure of E. coli threonyl tRNA synthetase in complex with a TM84 analogue

8OU8 の概要

• エントリーDOI: 10.2210/pdb8ou8/pdb
• 分子名称: Threonine--tRNA ligase, [(2~{S},4~{S},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-oxolan-2-yl]methoxy-~{N}-[(2~{S},3~{S})-2-azanyl-3-oxidanyl-butanoyl]phosphonamidic acid, DIMETHYL SULFOXIDE, ... (6 entities in total)
• 機能のキーワード: threonyl trna synthetase, e. coli, inhibitor, complex, rna binding protein
• 由来する生物種: Escherichia coli IAI1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97271.09

構造登録者

Rodriguez Buitrago, J.A.,Parisini, E.,Aigars, J. (登録日: 2023-04-22, 公開日: 2023-07-12, 最終更新日: 2023-09-06)

• 主引用文献: Buitrago, J.A.R.,Leitis, G.,Kanepe-Lapsa, I.,Rudnickiha, A.,Parisini, E.,Jirgensons, A.; Synthesis and evaluation of an agrocin 84 toxic moiety (TM84) analogue as a malarial threonyl tRNA synthetase inhibitor.; Org.Biomol.Chem., 21:5433-5439, 2023; PubMed: 37335076; DOI: 10.1039/d3ob00670k

実験手法

X-RAY DIFFRACTION (2.05 Å)