8OMJ

hKHK-C in complex with cpd 37

8OMJ の概要

• エントリーDOI: 10.2210/pdb8omj/pdb
• 分子名称: Ketohexokinase, [3-[[6-[(3~{a}~{R},6~{a}~{S})-2,3,3~{a},4,6,6~{a}-hexahydro-1~{H}-pyrrolo[3,4-c]pyrrol-5-yl]-3-cyano-4-(trifluoromethyl)pyridin-2-yl]amino]-4-methylsulfanyl-phenyl]methoxy-methyl-phosphinic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: khk, ketohexokinase, sugar binding kinase, inhibitor complex, sugar binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69400.30

構造登録者

Pautsch, A.,Ebenhoch, R. (登録日: 2023-03-31, 公開日: 2024-07-10)

• 主引用文献: Heine, N.,Weber, A.,Pautsch, A.,Gottschling, D.,Upheus, I.,Bauer, M.,Ebenhoch, R.,Nosse, B.,Kley, J.; Discovery of BI-9787, a Potent Zwitterionic KHK-Inhibitor with Oral Bioavailability; To Be Published,

実験手法

X-RAY DIFFRACTION (1.978 Å)