8OLU

Leishmania tarentolae proteasome 20S subunit in complex with 1-Benzyl-N-(3-(cyclopropylcarbamoyl)phenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide

8OLU の概要

• エントリーDOI: 10.2210/pdb8olu/pdb
• EMDBエントリー: 16963
• 分子名称: Proteasome subunit alpha type, Proteasome subunit beta, Proteasome beta 6 subunit, putative, ... (15 entities in total)
• 機能のキーワード: proteasome 20s subunit, unknown function
• 由来する生物種: Leishmania tarentolae; 詳細
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 848365.08

構造登録者

Rowland, P. (登録日: 2023-03-30, 公開日: 2023-08-09, 最終更新日: 2023-08-23)

• 主引用文献: Thomas, M.G.,McGonagle, K.,Rowland, P.,Robinson, D.A.,Dodd, P.G.,Camino-Diaz, I.,Campbell, L.,Cantizani, J.,Castaneda, P.,Conn, D.,Craggs, P.D.,Edwards, D.,Ferguson, L.,Fosberry, A.,Frame, L.,Goswami, P.,Hu, X.,Korczynska, J.,MacLean, L.,Martin, J.,Mutter, N.,Osuna-Cabello, M.,Paterson, C.,Pena, I.,Pinto, E.G.,Pont, C.,Riley, J.,Shishikura, Y.,Simeons, F.R.C.,Stojanovski, L.,Thomas, J.,Wrobel, K.,Young, R.J.,Zmuda, F.,Zuccotto, F.,Read, K.D.,Gilbert, I.H.,Marco, M.,Miles, T.J.,Manzano, P.,De Rycker, M.; Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors.; J.Med.Chem., 66:10413-10431, 2023; PubMed: 37506194; DOI: 10.1021/acs.jmedchem.3c00582

実験手法

ELECTRON MICROSCOPY (2.59 Å)