8OK0

Crystal structure of human NQO1 in complex with the inhibitor PMSF

Summary for 8OK0

Entry DOI	10.2210/pdb8ok0/pdb
Descriptor	NAD(P)H dehydrogenase [quinone] 1, FLAVIN-ADENINE DINUCLEOTIDE, phenylmethanesulfonic acid, ... (6 entities in total)
Functional Keywords	human nqo1, flavoenzyme, cancer, inhibitors, pmsf, flavoprotein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	127801.66
Authors	Martin-Garcia, J.M.,Grieco, A.,Ruiz-Fresneda, M.A. (deposition date: 2023-03-26, release date: 2023-11-01, Last modification date: 2023-11-22)
Primary citation	Grieco, A.,Ruiz-Fresneda, M.A.,Gomez-Mulas, A.,Pacheco-Garcia, J.L.,Quereda-Moraleda, I.,Pey, A.L.,Martin-Garcia, J.M. Structural dynamics at the active site of the cancer-associated flavoenzyme NQO1 probed by chemical modification with PMSF. Febs Lett., 597:2687-2698, 2023 Cited by PubMed: 37726177 DOI: 10.1002/1873-3468.14738 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation