8OJS
Crystal structure of the human IgD Fab - structure Fab1
Summary for 8OJS
| Entry DOI | 10.2210/pdb8ojs/pdb |
| Descriptor | Human IgD Fab light chain, Human IgD Fab heavy chain, PHOSPHATE ION, ... (5 entities in total) |
| Functional Keywords | fab, antibody, immunoglobulin, immune system |
| Biological source | Homo sapiens More |
| Total number of polymer chains | 4 |
| Total formula weight | 96494.10 |
| Authors | Davies, A.M.,Beavil, R.L.,McDonnell, J.M. (deposition date: 2023-03-24, release date: 2023-06-14, Last modification date: 2024-10-16) |
| Primary citation | Davies, A.M.,Beavil, R.L.,Barbolov, M.,Sandhar, B.S.,Gould, H.J.,Beavil, A.J.,Sutton, B.J.,McDonnell, J.M. Crystal structures of the human IgD Fab reveal insights into C H 1 domain diversity. Mol.Immunol., 159:28-37, 2023 Cited by PubMed Abstract: Antibodies of the IgD isotype remain the least well characterized of the mammalian immunoglobulin isotypes. Here we report three-dimensional structures for the Fab region of IgD, based on four different crystal structures, at resolutions of 1.45-2.75 Å. These IgD Fab crystals provide the first high-resolution views of the unique Cδ1 domain. Structural comparisons identify regions of conformational diversity within the Cδ1 domain, as well as among the homologous domains of Cα1, Cγ1 and Cμ1. The IgD Fab structure also possesses a unique conformation of the upper hinge region, which may contribute to the overall disposition of the very long linker sequence between the Fab and Fc regions found in human IgD. Structural similarities observed between IgD and IgG, and differences with IgA and IgM, are consistent with predicted evolutionary relationships for the mammalian antibody isotypes. PubMed: 37267832DOI: 10.1016/j.molimm.2023.05.006 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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