8OJS

Crystal structure of the human IgD Fab - structure Fab1

8OJS の概要

• エントリーDOI: 10.2210/pdb8ojs/pdb
• 分子名称: Human IgD Fab light chain, Human IgD Fab heavy chain, PHOSPHATE ION, ... (5 entities in total)
• 機能のキーワード: fab, antibody, immunoglobulin, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 96494.10

構造登録者

Davies, A.M.,Beavil, R.L.,McDonnell, J.M. (登録日: 2023-03-24, 公開日: 2023-06-14, 最終更新日: 2024-10-16)

主引用文献

Davies, A.M.,Beavil, R.L.,Barbolov, M.,Sandhar, B.S.,Gould, H.J.,Beavil, A.J.,Sutton, B.J.,McDonnell, J.M.
Crystal structures of the human IgD Fab reveal insights into C H 1 domain diversity.
Mol.Immunol., 159:28-37, 2023

PubMed Abstract: Antibodies of the IgD isotype remain the least well characterized of the mammalian immunoglobulin isotypes. Here we report three-dimensional structures for the Fab region of IgD, based on four different crystal structures, at resolutions of 1.45-2.75 Å. These IgD Fab crystals provide the first high-resolution views of the unique Cδ1 domain. Structural comparisons identify regions of conformational diversity within the Cδ1 domain, as well as among the homologous domains of Cα1, Cγ1 and Cμ1. The IgD Fab structure also possesses a unique conformation of the upper hinge region, which may contribute to the overall disposition of the very long linker sequence between the Fab and Fc regions found in human IgD. Structural similarities observed between IgD and IgG, and differences with IgA and IgM, are consistent with predicted evolutionary relationships for the mammalian antibody isotypes.

PubMed: 37267832
DOI: 10.1016/j.molimm.2023.05.006

実験手法

X-RAY DIFFRACTION (2.75 Å)