8OJI

Galectin-3 in complex with Methyl 2,6-anhydro-3-deoxy-3-S-(b-D-galactopyranosyl)-3-thio-D-glycero-L-altro-heptonate

8OJI の概要

• エントリーDOI: 10.2210/pdb8oji/pdb
• 分子名称: Galectin-3, CHLORIDE ION, 1-thio-beta-D-galactopyranose, ... (5 entities in total)
• 機能のキーワード: sugar binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16174.37

構造登録者

Tsagkarakou, A.S.,Leonidas, D.D. (登録日: 2023-03-24, 公開日: 2023-09-13, 最終更新日: 2023-09-20)

• 主引用文献: Lazar, L.,Tsagkarakou, A.S.,Stravodimos, G.,Kontopidis, G.,Leffler, H.,Nilsson, U.J.,Somsak, L.,Leonidas, D.D.; Strong Binding of C -Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds.; J.Med.Chem., 66:12420-12431, 2023; PubMed: 37658813; DOI: 10.1021/acs.jmedchem.3c00882

実験手法

X-RAY DIFFRACTION (1.75 Å)