8OIZ

Crystal structure of human CRBN-DDB1 in complex with Pomalidomide

8OIZ の概要

• エントリーDOI: 10.2210/pdb8oiz/pdb
• 分子名称: DNA damage-binding protein 1, Protein cereblon, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: e3-ligase, degradation, glue, protac, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 175595.39

構造登録者

Le Bihan, Y.-V.,Cabry, M.P.,van Montfort, R.L.M. (登録日: 2023-03-23, 公開日: 2023-07-19, 最終更新日: 2023-12-13)

• 主引用文献: Bouguenina, H.,Scarpino, A.,O'Hanlon, J.A.,Warne, J.,Wang, H.Z.,Wah Hak, L.C.,Sadok, A.,McAndrew, P.C.,Stubbs, M.,Pierrat, O.A.,Hahner, T.,Cabry, M.P.,Le Bihan, Y.V.,Mitsopoulos, C.,Sialana, F.J.,Roumeliotis, T.I.,Burke, R.,van Montfort, R.L.M.,Choudhari, J.,Chopra, R.,Caldwell, J.J.,Collins, I.; A Degron Blocking Strategy Towards Improved CRL4 CRBN Recruiting PROTAC Selectivity.; Chembiochem, 24:e202300351-e202300351, 2023; PubMed: 37418539; DOI: 10.1002/cbic.202300351

実験手法

X-RAY DIFFRACTION (2.5 Å)