8KCU
Cryo-EM structure of human gamma-secretase in complex with MK-0752
Summary for 8KCU
| Entry DOI | 10.2210/pdb8kcu/pdb |
| EMDB information | 37110 |
| Descriptor | Presenilin-1, CHOLESTEROL, Nicastrin, ... (10 entities in total) |
| Functional Keywords | intramembrane protease, gamma-secretase, gamma-secretase inhibitor, membrane protein, membrane protein-hydrolase complex |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 178935.36 |
| Authors | |
| Primary citation | Guo, X.,Li, H.,Kai, U.,Yan, C.,Lei, J.,Zhou, R.,Shi, Y. Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published, |
| Experimental method |
Structure validation
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