8K9W

Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 4 (ADKI4)

8K9W の概要

• エントリーDOI: 10.2210/pdb8k9w/pdb
• 分子名称: Lysine--tRNA ligase, ~{N}2-(2-methoxyphenyl)-~{N}4-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• 機能のキーワード: lysyl-trna synthetase, ligase
• 由来する生物種: Plasmodium falciparum (isolate Camp / Malaysia)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 120751.67

構造登録者

Zhou, J.,Xia, M.,Yang, G.,Li, P.,Fang, P. (登録日: 2023-08-01, 公開日: 2024-06-26, 最終更新日: 2024-07-03)

• 主引用文献: Zhou, J.,Xia, M.,Huang, Z.,Qiao, H.,Yang, G.,Qian, Y.,Li, P.,Zhang, Z.,Gao, X.,Jiang, L.,Wang, J.,Li, W.,Fang, P.; Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors.; Commun Biol, 7:742-742, 2024; PubMed: 38890421; DOI: 10.1038/s42003-024-06455-4

実験手法

X-RAY DIFFRACTION (2.3 Å)