8K9V
Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 3 (ADKI3)
Summary for 8K9V
Entry DOI | 10.2210/pdb8k9v/pdb |
Descriptor | Lysine--tRNA ligase, LYSINE, ~{N}4-(2,5-dimethoxyphenyl)-~{N}2-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine, ... (5 entities in total) |
Functional Keywords | lysyl-trna synthetase, ligase |
Biological source | Plasmodium falciparum (isolate Camp / Malaysia) |
Total number of polymer chains | 2 |
Total formula weight | 120807.74 |
Authors | |
Primary citation | Zhou, J.,Xia, M.,Huang, Z.,Qiao, H.,Yang, G.,Qian, Y.,Li, P.,Zhang, Z.,Gao, X.,Jiang, L.,Wang, J.,Li, W.,Fang, P. Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors. Commun Biol, 7:742-742, 2024 Cited by PubMed: 38890421DOI: 10.1038/s42003-024-06455-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
Download full validation report