8K9S

Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 1 (ADKI1)

8K9S の概要

• エントリーDOI: 10.2210/pdb8k9s/pdb
• 分子名称: Lysine--tRNA ligase, LYSINE, methyl 4-methoxy-3-[[4-[(2-propan-2-ylsulfonylphenyl)amino]-1,3,5-triazin-2-yl]amino]benzoate, ... (5 entities in total)
• 機能のキーワード: lysyl-trna synthetase, ligase
• 由来する生物種: Plasmodium falciparum (isolate Camp / Malaysia)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 120966.90

構造登録者

Zhou, J.,Xia, M.,Yang, G.,Li, P.,Fang, P. (登録日: 2023-08-01, 公開日: 2024-06-26, 最終更新日: 2024-07-03)

• 主引用文献: Zhou, J.,Xia, M.,Huang, Z.,Qiao, H.,Yang, G.,Qian, Y.,Li, P.,Zhang, Z.,Gao, X.,Jiang, L.,Wang, J.,Li, W.,Fang, P.; Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors.; Commun Biol, 7:742-742, 2024; PubMed: 38890421; DOI: 10.1038/s42003-024-06455-4

実験手法

X-RAY DIFFRACTION (2.35 Å)