8K7G
Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol
8K7G の概要
エントリーDOI | 10.2210/pdb8k7g/pdb |
分子名称 | Alpha-galactosidase A, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
機能のキーワード | alpha-galactosidase, glycosidase, iminosugar, hydrolase |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 93863.86 |
構造登録者 | |
主引用文献 | Li, H.Y.,Lin, H.Y.,Chang, S.K.,Chiu, Y.T.,Hou, C.C.,Ko, T.P.,Huang, K.F.,Niu, D.M.,Cheng, W.C. Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au, 4:908-918, 2024 Cited by PubMed: 38559739DOI: 10.1021/jacsau.3c00684 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.32 Å) |
構造検証レポート
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