8K7D

Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol

8K7D の概要

• エントリーDOI: 10.2210/pdb8k7d/pdb
• 分子名称: Alpha-galactosidase A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: alpha-galactosidase, glycosidase, iminosugar, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 93854.88

構造登録者

Li, H.Y.,Huang, K.F.,Ko, T.P.,Cheng, W.C. (登録日: 2023-07-26, 公開日: 2024-04-10)

• 主引用文献: Li, H.Y.,Lin, H.Y.,Chang, S.K.,Chiu, Y.T.,Hou, C.C.,Ko, T.P.,Huang, K.F.,Niu, D.M.,Cheng, W.C.; Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase.; Jacs Au, 4:908-918, 2024; PubMed: 38559739; DOI: 10.1021/jacsau.3c00684

実験手法

X-RAY DIFFRACTION (2.61 Å)