8K5Y

Crystal structure of human proMMP-9 catalytic domain in complex with inhibitor

8K5Y の概要

• エントリーDOI: 10.2210/pdb8k5y/pdb
• 分子名称: Matrix metalloproteinase-9, ZINC ION, CALCIUM ION, ... (6 entities in total)
• 機能のキーワード: mmp-9, 92 kda gelatinase, 92 kda type iv collagenase, gelatinase b, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55714.99

構造登録者

Kamitani, M.,Mima, M.,Nishikawa-Shimono, R. (登録日: 2023-07-24, 公開日: 2023-12-06)

• 主引用文献: Nishikawa-Shimono, R.,Kuwabara, M.,Fujisaki, S.,Matsuda, D.,Endo, M.,Kamitani, M.,Futamura, A.,Nomura, Y.,Yamaguchi-Sasaki, T.,Yabuuchi, T.,Yamaguchi, C.,Tanaka-Yamamoto, N.,Satake, S.,Abe-Sato, K.,Funayama, K.,Sakata, M.,Takahashi, S.,Hirano, K.,Fukunaga, T.,Uozumi, Y.,Kato, S.,Tamura, Y.,Nakamori, T.,Mima, M.,Mishima-Tsumagari, C.,Nozawa, D.,Imai, Y.,Asami, T.; Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation.; Bioorg.Med.Chem.Lett., 97:129541-129541, 2023; PubMed: 37952596; DOI: 10.1016/j.bmcl.2023.129541

実験手法

X-RAY DIFFRACTION (1.52 Å)