8JVD

Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening

8JVD の概要

• エントリーDOI: 10.2210/pdb8jvd/pdb
• 分子名称: Ubiquitin-conjugating enzyme E2 T, 5-fluoranyl-1,3-benzoxazol-2-amine (3 entities in total)
• 機能のキーワード: ube2t; ubiquitination; fragment-based drug discovery, ligase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17982.72

構造登録者

Anantharajan, J.,Baburajendran, N. (登録日: 2023-06-28, 公開日: 2024-02-28)

• 主引用文献: Loh, Y.Y.,Anantharajan, J.,Huang, Q.,Xu, W.,Fulwood, J.,Ng, H.Q.,Ng, E.Y.,Gea, C.Y.,Choong, M.L.,Tan, Q.W.,Koh, X.,Lim, W.H.,Nacro, K.,Cherian, J.,Baburajendran, N.,Ke, Z.,Kang, C.; Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening.; Protein Sci., 33:e4904-e4904, 2024; PubMed: 38358126; DOI: 10.1002/pro.4904

実験手法

X-RAY DIFFRACTION (1.696 Å)