8JMZ

FGFR1 kinase domain with sulfatinib

8JMZ の概要

• エントリーDOI: 10.2210/pdb8jmz/pdb
• 分子名称: Fibroblast growth factor receptor 1, N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: fibroblast growth factor receptor 1, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72538.96

構造登録者

Chen, X.J.,Lin, Q.M.,Chen, Y.H. (登録日: 2023-06-05, 公開日: 2024-03-27)

• 主引用文献: Lin, Q.,Dai, S.,Qu, L.,Lin, H.,Guo, M.,Wei, H.,Chen, Y.,Chen, X.; Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R.; Commun Chem, 7:3-3, 2024; PubMed: 38172256; DOI: 10.1038/s42004-023-01084-0

実験手法

X-RAY DIFFRACTION (1.988 Å)