8JIQ

Cryo-EM structure of the GLP-1R/GCGR dual agonist Peptide 15-bound human GCGR-Gs complex

8JIQ の概要

• エントリーDOI: 10.2210/pdb8jiq/pdb
• EMDBエントリー: 36324
• 分子名称: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: g protein-coupled receptor, ligand recognition, receptor activation, unimolecular dual agonist, structural protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 156703.10

構造登録者

Yang, L.,Zhou, Q.T.,Dai, A.T.,Zhao, F.H.,Chang, R.L.,Ying, T.L.,Wu, B.L.,Yang, D.H.,Wang, M.W.,Cong, Z.T. (登録日: 2023-05-27, 公開日: 2023-09-13)

• 主引用文献: Li, Y.,Zhou, Q.,Dai, A.,Zhao, F.,Chang, R.,Ying, T.,Wu, B.,Yang, D.,Wang, M.W.,Cong, Z.; Structural analysis of the dual agonism at GLP-1R and GCGR.; Proc.Natl.Acad.Sci.USA, 120:e2303696120-e2303696120, 2023; PubMed: 37549266; DOI: 10.1073/pnas.2303696120

実験手法

ELECTRON MICROSCOPY (3.4 Å)