8JII
Cryo-EM structure of compound 9n and niacin bound ketone body receptor HCAR2-Gi signaling complex
Summary for 8JII
Entry DOI | 10.2210/pdb8jii/pdb |
EMDB information | 36312 36492 36493 36506 |
Descriptor | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... (9 entities in total) |
Functional Keywords | complex, agonist, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 163026.13 |
Authors | Zhao, C.,Tian, X.W.,Liu, Y.,Cheng, L.,Yan, W.,Shao, Z.H. (deposition date: 2023-05-26, release date: 2023-09-06, Last modification date: 2023-09-27) |
Primary citation | Zhao, C.,Wang, H.,Liu, Y.,Cheng, L.,Wang, B.,Tian, X.,Fu, H.,Wu, C.,Li, Z.,Shen, C.,Yu, J.,Yang, S.,Hu, H.,Fu, P.,Ma, L.,Wang, C.,Yan, W.,Shao, Z. Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation. Mol.Cell, 83:3171-, 2023 Cited by PubMed: 37597514DOI: 10.1016/j.molcel.2023.07.030 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.17 Å) |
Structure validation
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