8JII

Cryo-EM structure of compound 9n and niacin bound ketone body receptor HCAR2-Gi signaling complex

8JII の概要

• エントリーDOI: 10.2210/pdb8jii/pdb
• EMDBエントリー: 36312 36492 36493 36506
• 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... (9 entities in total)
• 機能のキーワード: complex, agonist, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 163026.13

構造登録者

Zhao, C.,Tian, X.W.,Liu, Y.,Cheng, L.,Yan, W.,Shao, Z.H. (登録日: 2023-05-26, 公開日: 2023-09-06, 最終更新日: 2023-09-27)

• 主引用文献: Zhao, C.,Wang, H.,Liu, Y.,Cheng, L.,Wang, B.,Tian, X.,Fu, H.,Wu, C.,Li, Z.,Shen, C.,Yu, J.,Yang, S.,Hu, H.,Fu, P.,Ma, L.,Wang, C.,Yan, W.,Shao, Z.; Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.; Mol.Cell, 83:3171-, 2023; PubMed: 37597514; DOI: 10.1016/j.molcel.2023.07.030

実験手法

ELECTRON MICROSCOPY (3.17 Å)