8JDQ

Crystal structure of H405A mLDHD in complex with D-2-hydroxyisocaproic acid

Summary for 8JDQ

• Entry DOI: 10.2210/pdb8jdq/pdb
• Descriptor: Probable D-lactate dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, (2R)-2-hydroxy-4-methylpentanoic acid, ... (4 entities in total)
• Functional Keywords: d-lactate dehydrogenase, ldhd, 2-hydroxyacid, oxidoreductase
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 1
• Total formula weight: 51303.50

Authors

Jin, S.,Chen, X.,Yang, J.,Ding, J. (deposition date: 2023-05-15, release date: 2023-10-18, Last modification date: 2024-02-21)

• Primary citation: Jin, S.,Chen, X.,Yang, J.,Ding, J.; Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.; Nat Commun, 14:6638-6638, 2023; PubMed: 37863926; DOI: 10.1038/s41467-023-42456-3

Experimental method

X-RAY DIFFRACTION (1.39 Å)