8JBA
Discovery and Crystallography Study of Novel Oxadiazole Analogs as Small Molecule PD-1/PD-L1 inhibitors
8JBA の概要
エントリーDOI | 10.2210/pdb8jba/pdb |
分子名称 | Programmed cell death 1 ligand 1, (2~{S})-2-[[3-[[5-[(2-methyl-3-phenyl-phenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]methylamino]-3-oxidanyl-propanoic acid (3 entities in total) |
機能のキーワード | immune checkpoint, dimer, inhibitor, immune system |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 29863.10 |
構造登録者 | |
主引用文献 | Liu, J.,Cheng, Y.,Yuan, L.,Liu, T.,Ruan, Y.,Ren, Y.,Li, L.,Jiang, S.,Xiao, Y.,Chen, J. Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents. J.Med.Chem., 66:13172-13188, 2023 Cited by PubMed: 37674362DOI: 10.1021/acs.jmedchem.3c01141 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.6 Å) |
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