8JB4

lipopolysaccharide-binding domain-LBDB

Summary for 8JB4

• Entry DOI: 10.2210/pdb8jb4/pdb
• Descriptor: Antilipopolysaccharide factor D (1 entity in total)
• Functional Keywords: lipopolysaccharide-binding domain, anti-lipopolysaccharide factor, antimicrobial protein
• Biological source: Penaeus japonicus
• Total number of polymer chains: 1
• Total formula weight: 2852.52

Authors

Huang, J.,Qin, Z. (deposition date: 2023-05-08, release date: 2024-03-13, Last modification date: 2025-03-19)

Primary citation

Zhang, H.,Wang, Y.,Zhu, Y.,Huang, P.,Gao, Q.,Li, X.,Chen, Z.,Liu, Y.,Jiang, J.,Gao, Y.,Huang, J.,Qin, Z.
Machine learning and genetic algorithm-guided directed evolution for the development of antimicrobial peptides.
J Adv Res, 68:415-428, 2025

PubMed Abstract: Antimicrobial peptides (AMPs) are valuable alternatives to traditional antibiotics, possess a variety of potent biological activities and exhibit immunomodulatory effects that alleviate difficult-to-treat infections. Clarifying the structure-activity relationships of AMPs can direct the synthesis of desirable peptide therapeutics.

PubMed: 38431124
DOI: 10.1016/j.jare.2024.02.016

Experimental method

SOLUTION NMR