8JAO
Crystal structure of B1 IMP-1 MBL in complex with 2-amino-5-phenethylthiazole-4-carboxylic acid
Summary for 8JAO
Entry DOI | 10.2210/pdb8jao/pdb |
Descriptor | Beta-lactamase, ZINC ION, 2-azanyl-5-(2-phenylethyl)-1,3-thiazole-4-carboxylic acid, ... (4 entities in total) |
Functional Keywords | beta-lactamase class b imp-1, hydrolase |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 2 |
Total formula weight | 49169.51 |
Authors | |
Primary citation | Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B. Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. J.Med.Chem., 66:13746-13767, 2023 Cited by PubMed: 37791640DOI: 10.1021/acs.jmedchem.3c01189 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.194 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)