8J83

Crystal structure of formate dehydrogenase from Methylorubrum extorquens AM1

8J83 の概要

• エントリーDOI: 10.2210/pdb8j83/pdb
• 分子名称: Tungsten-containing formate dehydrogenase alpha subunit, Tungsten-containing formate dehydrogenase beta subunit, 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, ... (10 entities in total)
• 機能のキーワード: oxidoreductase, formate dehydrogenase, nad+ dependent, tungsten-containing, metallopterin guanine dinucleotide
• 由来する生物種: Methylorubrum extorquens AM1; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 174307.60

構造登録者

Kobayashi, A.,Taketa, M.,Sowa, K.,Kano, K.,Higuchi, Y.,Ogata, H. (登録日: 2023-04-29, 公開日: 2023-10-11)

主引用文献

Kobayashi, A.,Taketa, M.,Sowa, K.,Kano, K.,Higuchi, Y.,Ogata, H.
Structure and function relationship of formate dehydrogenases: an overview of recent progress.
Iucrj, 10:544-554, 2023

PubMed Abstract: Formate dehydrogenases (FDHs) catalyze the two-electron oxidation of formate to carbon dioxide. FDHs can be divided into several groups depending on their subunit composition and active-site metal ions. Metal-dependent (Mo- or W-containing) FDHs from prokaryotic organisms belong to the superfamily of molybdenum enzymes and are members of the dimethylsulfoxide reductase family. In this short review, recent progress in the structural analysis of FDHs together with their potential biotechnological applications are summarized.

PubMed: 37668215
DOI: 10.1107/S2052252523006437

実験手法

X-RAY DIFFRACTION (2.4 Å)