8J63
The crystal structure of TrkA kinase in complex with 4^6-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-11-oxo-5-oxa-10,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide
8J63 の概要
エントリーDOI | 10.2210/pdb8j63/pdb |
分子名称 | High affinity nerve growth factor receptor, 4^6-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-11-oxo-5-oxa-10,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide (2 entities in total) |
機能のキーワード | transferase |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 34563.80 |
構造登録者 | |
主引用文献 | Wang, Z.,Wang, J.,Wang, Y.,Xiang, S.,Zhou, H.,Song, S.,Song, X.,Tu, Z.,Zhou, Y.,Ding, K.,Zhang, Z.M.,Zhang, Z.,Lu, X. Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations. J.Med.Chem., 66:12950-12965, 2023 Cited by PubMed: 37676745DOI: 10.1021/acs.jmedchem.3c00899 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.0005 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード