8J5H

Crystal structure of kinase AbmG in complex with 4'-hydroxy-4'-thiocytidine

Summary for 8J5H

Entry DOI	10.2210/pdb8j5h/pdb
Descriptor	Deoxyadenosine/deoxycytidine kinase, 4-azanyl-1-[(2~{R},3~{R},4~{S},5~{S})-5-(hydroxymethyl)-3,4,5-tris(oxidanyl)thiolan-2-yl]pyrimidin-2-one, NITRATE ION, ... (4 entities in total)
Functional Keywords	albomycin, biosynthesis, transferase
Biological source	Streptomyces sp. ATCC 700974
Total number of polymer chains	1
Total formula weight	27742.18
Authors	Ushimaru, R.,Mori, T.,Liu, H.-w.,Abe, I. (deposition date: 2023-04-22, release date: 2024-04-24, Last modification date: 2025-11-05)
Primary citation	Zheng, Z.,Ushimaru, R.,Mori, T.,Ruszczycky, M.W.,Abe, I.,Liu, H.W. Biosynthesis of the Thiofuranose Core in Albomycin Requires a Versatile Enzyme AbmG That Catalyzes Net Dehydration via Cryptic Phosphorylation J.Am.Chem.Soc., 147:34143-34149, 2025 Cited by DOI: 10.1021/jacs.5c12827 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation