8J1F
GSK101 bound state of mTRPV4
Summary for 8J1F
Entry DOI | 10.2210/pdb8j1f/pdb |
EMDB information | 35921 |
Descriptor | Transient receptor potential cation channel subfamily V member 4, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide (2 entities in total) |
Functional Keywords | mtrpv4, structural protein, membrane protein |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 4 |
Total formula weight | 321069.17 |
Authors | Zhen, W.X.,Yang, F. (deposition date: 2023-04-12, release date: 2023-08-09, Last modification date: 2024-05-29) |
Primary citation | Zhen, W.,Zhao, Z.,Chang, S.,Chen, X.,Wan, Y.,Yang, F. Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9:70-70, 2023 Cited by PubMed: 37429860DOI: 10.1038/s41421-023-00579-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.62 Å) |
Structure validation
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